Multifunctional theranostic nanoparticles for multi-modal imaging-guided CAR-T immunotherapy and chemo-photothermal combinational therapy of non-Hodgkin's lymphoma

Author:

Shi Bowen1,Li Dan2,Yao Weiwu3,Wang Wenfang1,Jiang Jiang1ORCID,Wang Ruiheng2,Yan Fuhua1,Liu Han2,Zhang Huan2ORCID,Ye Jian45ORCID

Affiliation:

1. Department of Radiology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China

2. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China

3. Department of Radiology, Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200050, P. R. China

4. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China

5. Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

Abstract

A biocompatible FA-Gd-GERTs@Ibrutinib nanocomposite was developed that exhibits powerful theranostic performance for the CT/MR/SERS-imaging-guided CAR-T cell/chemo/photothermal therapy of tumors.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Shanghai Jiao Tong University

Shanghai Key Laboratory of Gynecologic Oncology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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