A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy-Reference-Cited by-同舟云学术

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy

Published:2014-08-21 Issue:8 Volume:124 Page:1277-1287
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Philip Brian¹,Kokalaki Evangelia¹,Mekkaoui Leila¹,Thomas Simon¹,Straathof Karin¹,Flutter Barry¹,Marin Virna²,Marafioti Teresa¹,Chakraverty Ronjon¹,Linch David¹,Quezada Sergio A.¹,Peggs Karl S.¹,Pule Martin¹

Affiliation:

1. UCL Cancer Institute, University College London, London, United Kingdom; and

2. Department of Pediatrics, Centro di Ricerca Matilde Tettamanti, University of Milano-Bicocca, Milan, Italy

Abstract

Key Points Marker genes enable detection and selection of T cells, whereas suicide genes enable selective destruction of T cells in case of toxicity. RQR8 is a 136-amino-acid epitope-based marker/suicide gene that enables clinical selection, cell tracking, and deletion in case of toxicity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/8/1277/1382207/1277.pdf

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