Discovery of a 3,4,5-trisubstituted-1,2,4-triazole agonist with high affinity and selectivity at the somatostatin subtype-4 (sst4) receptor-Reference-Cited by-同舟云学术

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Discovery of a 3,4,5-trisubstituted-1,2,4-triazole agonist with high affinity and selectivity at the somatostatin subtype-4 (sst4) receptor

Published:2018 Issue:12 Volume:9 Page:2083-2090
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Daryaei Iman¹²³⁴⁵^ORCID,Sandoval Karin¹²³⁴⁵,Witt Ken¹²³⁴⁵,Kontoyianni Maria¹²³⁴⁵,Michael Crider A.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. School of Pharmacy

3. Southern Illinois University Edwardsville

4. Edwardsville

5. 62026-2000 USA

Abstract

A 1,2,4-triazole has been discovered with high affinity and selectivity at the somatostatin sub-type 4 (sst₄) receptor.

Funder

National Institute On Aging

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00388B

Reference46 articles.

1. Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

2. Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.

3. All Five Cloned Human Somatostatin Receptors (hSSTR1-5) Are Functionally Coupled to Adenylyl Cyclase

4. Recent Advances in the Development of Nonpeptide Somatostatin Receptor Ligands

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2. Exploration of Somatostatin Binding Mechanism to Somatostatin Receptor Subtype 4;International Journal of Molecular Sciences;2022-06-21

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5. Synthesis and structure–activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment;RSC Medicinal Chemistry;2021

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