Synthesis and structure–activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment-Reference-Cited by-同舟云学术

Synthesis and structure–activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment

Published:2021 Issue:8 Volume:12 Page:1352-1365
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Neumann William L.¹,Sandoval Karin E.¹,Mobayen Shirin¹,Minaeian Mahsa¹,Kukielski Stephen G.¹,Srabony Khush N.¹^ORCID,Frare Rafael¹,Slater Olivia¹,Farr Susan A.²,Niehoff Michael L.²,Hospital Audrey¹,Kontoyianni Maria¹,Crider A. Michael¹^ORCID,Witt Ken A.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA

2. Research and Development Service, VA Medical Center, Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA

Abstract

3,4,5-Trisubstituted-1,2,4-triazole somatostatin receptor-4 agonist SAR.

Funder

National Institute on Aging

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00044F

Reference68 articles.

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2. Isolation, structure, biological characterization, and synthesis of beta-[Tyr9]melanotropin-(9-18) decapeptide from pig hypothalami.

3. Somatostatinergic systems in brain: Networks and functions

4. Disinhibition in learning and memory circuits: New vistas for somatostatin interneurons and long-term synaptic plasticity

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