Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies-Reference-Cited by-同舟云学术

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Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies

Published:2020 Issue:7 Volume:10 Page:3626-3635
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shi Cheng-Cheng¹²³⁴⁵,Chen Tian-Ran⁶⁷⁸⁵⁹,Zhang Qi-Hua¹⁰¹¹¹²¹³⁸,Wei Ling-Hua¹⁴¹⁵¹⁶⁴⁵,Huang Chao⁶⁷⁸⁵,Zhu Ya-Di⁶⁷⁸⁵,Liu Hai-Bin⁹¹⁷⁵,Bai Ya-Kun¹⁴¹⁵¹⁶⁴⁵,Wang Fang-Jun¹⁸¹⁹¹³²⁰⁵^ORCID,Guo Wen-Zhi¹⁴¹⁵¹⁶⁴⁵,Zhang Li-Rong¹²³⁴⁵,Ge Guang-Bo⁶⁷⁸⁵¹⁸^ORCID

Affiliation:

1. Department of Pharmacology

2. School of Basic Medical Sciences

3. Zhengzhou University

4. Zhengzhou

5. China

6. Institute of Interdisciplinary Integrative Medicine Research

7. Shanghai University of Traditional Chinese Medicine

8. Shanghai

9. National Engineering Research Center for Gelatin-based Traditional Chinese Medicine

10. CAS Key Laboratory of Receptor Research

11. Drug Discovery and Design Center

12. Shanghai Institute of Materia Medica

13. Chinese Academy of Sciences

14. Henan Key Laboratory of Digestive Organ Transplantation

15. Department of Hepatobiliary and Pancreatic Surgery

16. The First Affiliated Hospital of Zhengzhou University

17. Dong-E-E-Jiao Co. Ltd.

18. CAS Key Laboratory of Separation Sciences for Analytical Chemistry

19. Dalian Institute of Chemical Physics

20. Dalian

Abstract

Licochalcone A, a bioactive compound from licorice, displayed strong inhibition of thrombin.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Program of Shanghai Academic Research Leader

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA09203J

Reference61 articles.

1. Identification and inhibitory activity against α-thrombin of a novel anticoagulant peptide derived from oyster (Crassostrea gigas) protein

2. Triggers, targets and treatments for thrombosis

3. Direct Thrombin Inhibitors

4. Direct Thrombin Inhibitors

5. The market for oral anticoagulants

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1. Chalcone derivatives as novel, potent and selective inhibitors against human Notum: Structure–activity relationships and biological evaluations;Chinese Chemical Letters;2024-03

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4. Phytochemical Analysis of the Methanolic Extract and Essential Oil from Leaves of Industrial Hemp Futura 75 Cultivar: Isolation of a New Cannabinoid Derivative and Biological Profile Using Computational Approaches;Plants;2022-06-24

5. Licorice (Glycyrrhiza glabra) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review;Plants;2021-11-26

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