Syntheses of α-CF3-α-quaternary ketones via p-quinone methides and their derivatization to compounds with successively congested stereogenic centers
Author:
Affiliation:
1. Division of Applied Chemistry
2. Institute of Engineering
3. Tokyo University of Agriculture and Technology
4. Koganei 184-8588
5. Japan
6. Department of Biomolecular Functional Engineering
7. Ibaraki University
8. Hitachi 316-8511
Abstract
NHC-catalyzed 1,6-conjugate additions of a variety of aldehydes to δ-CF3-δ-substituted p-quinone methides and their highly diastereoselective derivatization to compounds with successively congested stereogenic centers were performed.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00951B
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3. Visible Light-Induced Radical Cyclization of Tertiary Bromides with Isonitriles To Construct Trifluoromethylated Quaternary Carbon Center
4. Taming Radical Intermediates for the Construction of Enantioenriched Trifluoromethylated Quaternary Carbon Centers
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