Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation-Reference-Cited by-同舟云学术

Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation

Published:2017 Issue:2 Volume:19 Page:380-384
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Sehl Torsten¹²³⁴⁵,Bock Saskia¹²³⁴⁵,Marx Lisa¹²³⁴⁵,Maugeri Zaira¹²³⁴⁵^ORCID,Walter Lydia⁶⁷⁸⁵,Westphal Robert¹²³⁴⁵,Vogel Constantin⁹¹⁰¹¹⁵¹²,Menyes Ulf¹³¹⁴⁵,Erhardt Martin¹⁵¹⁶⁵,Müller Michael⁶⁷⁸⁵,Pohl Martina¹²³⁴⁵,Rother Dörte¹²³⁴⁵

Affiliation:

1. Institute of Bio- and Geosciences

2. IBG-1: Biotechnology

3. Forschungszentrum Jülich GmbH

4. 52425 Jülich

5. Germany

6. Institute of Pharmaceutical Sciences

7. Albert-Ludwigs-University Freiburg

8. 79104 Freiburg

9. Institute of Technical Biochemistry

10. University of Stuttgart

11. 70569 Stuttgart

12. TRUMPF GmbH+Co.KG

13. Enzymicals AG

14. 17489 Greifswald

15. HERBRAND PharmaChemicals GmbH

16. 77723 Gegenbach

Abstract

By the combination of biocatalyst design and reaction engineering, the so far not stereoselectively accessible (S)-phenylacetylcarbinol could be enzymatically synthesized with product concentrations >48 g L⁻¹ and an enantiomeric excess up to 97%.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/GC/C6GC01803C

Reference23 articles.

1. Biocatalysis for pharmaceutical intermediates: the future is now

2. Biocatalytic Strategies for the Asymmetric Synthesis of α-Hydroxy Ketones

3. Enzymatic asymmetric synthesis by decarboxylases

4. Thiamine-Diphosphate-Dependent Enzymes as Catalytic Tools for the Asymmetric Benzoin-Type Reaction

5. Enantioselective C–C bond synthesis catalysed by enzymes

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