Accurate quantification of carboplatin adducts with serum proteins by monolithic chromatography coupled to ICPMS with isotope dilution analysis

Abstract

This work demonstrates for the first time the potential of monolithic chromatography coupled to double species-specific isotope dilution analysis (IDA) inductively coupled plasma mass spectrometry (ICPMS) for the detection and accurate quantification of adducts of plasma/serum proteins with carboplatin, an anti-cancer drug.