Accurate quantification of carboplatin adducts with serum proteins by monolithic chromatography coupled to ICPMS with isotope dilution analysis

Author:

Larios Raquel12345ORCID,Del Castillo Busto M. Estela12ORCID,Garcia-Sar Daniel12675,Ward-Deitrich Christian12,Goenaga-Infante Heidi12ORCID

Affiliation:

1. LGC Limited

2. UK

3. Agilent Technologies

4. Madrid

5. Spain

6. AGQ Labs

7. Sevilla

Abstract

This work demonstrates for the first time the potential of monolithic chromatography coupled to double species-specific isotope dilution analysis (IDA) inductively coupled plasma mass spectrometry (ICPMS) for the detection and accurate quantification of adducts of plasma/serum proteins with carboplatin, an anti-cancer drug.

Funder

European Association of National Metrology Institutes

Department for Business, Energy and Industrial Strategy

Publisher

Royal Society of Chemistry (RSC)

Subject

Spectroscopy,Analytical Chemistry

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