Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery-Reference-Cited by-同舟云学术

Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery

Published:2022 Issue:26 Volume:13 Page:7780-7789
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wu Yapei¹,Fan Shihui¹,Dong Meng¹,Li Jinjing¹,Kong Chuilian¹,Zhuang Jie¹,Meng Xiaoting¹,Lu Shuaimin¹,Zhao Yibing¹,Wu Chuanliu¹^ORCID

Affiliation:

1. Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, P.R. China

Abstract

CPPC-paired disulfide-rich peptides with stable 3D structures have been discovered through rational library design and screening, providing unconventional peptide scaffolds for the development of new peptide therapeutics.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Program for Changjiang Scholars and Innovative Research Team in University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00924B

Reference45 articles.

1. Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins