Selection and evolution of disulfide-rich peptides <i>via</i> cellular protein quality control-Reference-Cited by-同舟云学术

Selection and evolution of disulfide-rich peptides via cellular protein quality control

Published:2023 Issue:13 Volume:14 Page:3668-3675
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Meng Xiaoting¹,Xu Chaoying¹,Fan Shihui¹,Dong Meng¹,Zhuang Jie¹,Duan Zengping¹,Zhao Yibing¹,Wu Chuanliu¹^ORCID

Affiliation:

1. Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, P. R. China

Abstract

A selection system leveraging cellular protein quality control (termed PQC-select) has been designed to select DRPs with robust foldability from random sequences, providing valuable scaffolds for developing peptide-based probes or therapeutics.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Program for Changjiang Scholars and Innovative Research Team in University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC05343H

Reference40 articles.

1. Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

2. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

3. Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

4. Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides

5. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

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