Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivo-Reference-Cited by-同舟云学术

Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivo

Published:2016 Issue:93 Volume:6 Page:90967-90972
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Choi Won Il¹²³⁴⁵,Sahu Abhishek⁶⁷⁸⁵,Vilos Cristian⁹¹⁰¹¹¹²¹³,Lee Jong Hyun⁶⁷⁸⁵,Kim Sunghyun¹²³⁴⁵,Hong Young Ki¹⁴¹⁵¹⁶⁵,Sul Donggeun¹⁷¹⁸¹⁹⁵,Hwang Sun Wook¹⁷¹⁸¹⁹⁵,Lee Sang Heon²⁰²¹¹⁸¹⁹⁵,Tae Giyoong⁶⁷⁸⁵

Affiliation:

1. Center for Convergence Bioceramic Materials

2. Convergence R&D Division

3. Korea Institute of Ceramic Engineering and Technology

4. Jinju-si

5. Republic of Korea

6. School of Materials Science and Engineering

7. Gwangju Institute of Science and Technology

8. Gwangju 61005

9. Laboratory of Nanomedicine and Targeted Delivery

10. Center for Integrative Medicine and Innovative Science

11. Faculty of Medicine

12. Center for Bioinformatics and Integrative Biology

13. Faculty of Biological Sciences

14. Department of Sports Medicine

15. Cheongju University

16. Cheongju-si

17. Graduate School of Medicine

18. Korea University

19. Seoul 136-701

20. Department of Physical Medicine and Rehabilitation

21. College of Medicine

Abstract

Chitosan functionalized nano-carriers could function as an efficient delivery carrier for local administration of chymopapain to reduce the side effect associated with chemonucleolysis.

Funder

Comisión Nacional de Investigación Científica y Tecnológica

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA17848K

Reference31 articles.

1. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease