Tuning molecular dynamics by hydration and confinement: antiplasticizing effect of water in hydrated prilocaine nanoclusters

Author:

Ruiz G. N.12345ORCID,Combarro-Palacios I.678910,McLain S. E.1112131415ORCID,Schwartz G. A.678910ORCID,Pardo L. C.12345ORCID,Cerveny S.678910ORCID,Macovez R.12345ORCID

Affiliation:

1. Grup de Caracterització de Materials

2. Departament de Física

3. Universitat Politècnica de Catalunya

4. EEBE

5. Campus Diagonal-Besòs

6. Centro de Física de Materiales

7. (CSIC-UPV/EHU)-Material Physics Centre (MPC)

8. Paseo Manuel de Lardizabal 5 (20018)

9. San Sebastián

10. Spain

11. Department of Biochemistry

12. University of Oxford

13. South Parks Road

14. Oxford OX1 3QU

15. UK

Abstract

Antiplasticizing effect of hydration vs. plasticizing effect of nanoconfinement in a molecular glass former.

Funder

Eusko Jaurlaritza

Ministerio de Economía y Competitividad

Generalitat de Catalunya

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference31 articles.

1. S. Yoshioka and V. J.Stella , Stability of drugs and dosage forms , Kluwer Academic Publishers , 2002

2. S. Ewing , A.Hussain , G.Collins , C.Roberts and E.Shalaev , Low-Temperature Mobility of Water in Sugar Glasses: Insights from Thermally Stimulated Current Study , Springer , New York, NY , 2016 , pp. 75–87

3. Water as a plasticizer: physico-chemical aspects of low-moisture polymeric systems

4. Beyond water activity: Recent advances based on an alternative approach to the assessment of food quality and safety

5. A Review on Methods and Theories to Describe the Glass Transition Phenomenon: Applications in Food and Pharmaceutical Products

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