Prevention of surface-induced thrombogenesis on poly(vinyl chloride)-Reference-Cited by-同舟云学术

Prevention of surface-induced thrombogenesis on poly(vinyl chloride)

Published:2015 Issue:44 Volume:3 Page:8623-8628
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Fedorov Kiril¹²³⁴,Jankowski Alexander⁵²³⁴,Sheikh Sonia⁵²³⁴,Blaszykowski Christophe⁶³⁴,Reheman Adili⁷⁸²³⁴,Romaschin Alexander⁹³⁴,Ni Heyu⁷⁸²³⁴,Thompson Michael¹²³⁴⁵

Affiliation:

1. Institute of Biomaterials & Biomedical Engineering

2. University of Toronto

3. Toronto

4. Canada

5. Department of Chemistry – St. George Campus

6. Econous Systems Inc.

7. Canadian Blood Services and the Department of Laboratory Medicine and Pathobiology

8. Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital

9. Keenan Research Centre and Clinical Biochemistry

Abstract

PVC is derivatized with an ultrathin MEG coating with remarkable antithrombogenicity. Assessed upon exposure to fluorescently-labelled human blood, at various shear rates and contact periods, platelet aggregation/clotting coverage is reduced by >95–99% for coatedvs. bare PVC surfaces.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TB/C5TB01582K

Reference26 articles.

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2. Modification of Poly(Vinyl Chloride) for Biocompatibility Improvement and Biomedical Application-Review

3. Foreign body reaction to biomaterials

4. Surface Chemistry Influences Implant Biocompatibility

5. Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

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