Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system-Reference-Cited by-同舟云学术

Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system

Published:2018 Issue:22 Volume:8 Page:11902-11907
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pamreddy Annapurna¹²³⁴⁵,Baijnath Sooraj¹²³⁴⁵,Naicker Tricia¹²³⁴⁵^ORCID,Ntshangase Sphamandla¹²³⁴⁵,Mdanda Sipho¹²³⁴⁵,Lubanyana Hlengekile¹²³⁴⁵,Kruger Hendrik G.¹²³⁴⁵^ORCID,Govender Thavendran¹²³⁴⁵^ORCID

Affiliation:

1. Catalysis and Peptide Research Unit

2. School of Health Sciences

3. University of KwaZulu-Natal

4. Durban 4000

5. South Africa

Abstract

Bedaquiline (BDQ) was administered to healthy Sprague-Dawley rats in order to determine its localisation in the brain using mass spectrometry imaging (MSI). This study shows that BDQ has the potential for targeting TB reservoirs in the CNS.

Funder

National Research Foundation

Inyuvesi Yakwazulu-Natali

South African Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA00984H

Reference42 articles.

1. World Health Organization , Global tuberculosis report 2016 , W. H. O. , Geneva, Switzerland , 2017