The downfall of TBA-354 – a possible explanation for its neurotoxicity via mass spectrometric imaging

Author:

Ntshangase Sphamandla1,Shobo Adeola1,Kruger Hendrik G.1,Asperger Arndt2,Niemeyer Dagmar2,Arvidsson Per I.13,Govender Thavendran1,Baijnath Sooraj1

Affiliation:

1. Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, South Africa,

2. Bruker Daltonik, GmbH, Bremen, Germany, and

3. Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Development of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Reference32 articles.

1. Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction

2. Arnaud CH. (2017). Pharma embraces imaging mass spec [online]. C&EN Chemical & Engineering News. Available from: http://cen.acs.org/articles/95/i23/Pharma-embraces-imaging-mass-spec.html [last accessed 7 Jun 2017]

3. Evidence for the presence of clofazimine and its distribution in the healthy mouse brain

4. Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry

5. Reversible brain MRI changes in acyclovir neurotoxicity

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