Investigation of ECD conformational transition mechanism of GLP-1R by molecular dynamics simulations and Markov state model-Reference-Cited by-同舟云学术

Investigation of ECD conformational transition mechanism of GLP-1R by molecular dynamics simulations and Markov state model

Published:2019 Issue:16 Volume:21 Page:8470-8481
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Zhang Jintu¹²³⁴⁵,Bai Qifeng¹²³⁴⁵^ORCID,Pérez-Sánchez Horacio⁶⁷⁸⁹,Shang Shuxia¹⁰⁴⁵¹¹,An Xiaoli¹²³⁴⁵,Yao Xiaojun¹⁰⁴⁵¹¹

Affiliation:

1. Key Lab of Preclinical Study for New Drugs of Gansu Province

2. Institute of Biochemistry and Molecular Biology

3. School of Basic Medical Sciences

4. Lanzhou University

5. Lanzhou

6. Computer Science Department

7. Universidad Católica San Antonio de Murcia (UCAM)

8. Murcia

9. Spain

10. College of Chemistry and Chemical Engineering

11. P. R. China

Abstract

As a member of the class B G protein-coupled receptors (GPCRs), the glucagon-like peptide-1 (GLP-1) can regulate the blood glucose level by binding to the glucagon-like peptide-1 receptor (GLP-1R).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP00080A

Reference43 articles.

1. Biology of Incretins: GLP-1 and GIP

2. Targeting the glucagon receptor family for diabetes and obesity therapy

3. Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

4. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

5. Glucagon-like peptide-1 analogues for type 2 diabetes

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