Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models-Reference-Cited by-同舟云学术

Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models

Published:2024-02-05 Issue:4 Volume:15 Page:844-853
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Li Mengrong¹²^ORCID,Zhang Xiaoxiao²,Li Shu³,Guo Jingjing³⁴^ORCID

Affiliation:

1. School of Physics and Astronomy & Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, China

2. College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China

3. Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China

4. Engineering Research Centre of Applied Technology on Machine Translation and Artificial Intelligence, Macao Polytechnic University, Macao 999078, China

Funder

Macao Polytechnic University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00747

Reference57 articles.

1. Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity

2. Structural insights into differences in G protein activation by family A and family B GPCRs

3. Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide–Target Interactions

4. Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

5. Delineating the activation mechanism and conformational landscape of a class B G protein-coupled receptor glucagon receptor

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