Application of PLGA nanoparticles to enhance the action of duloxetine on microglia in neuropathic pain-Reference-Cited by-同舟云学术

Application of PLGA nanoparticles to enhance the action of duloxetine on microglia in neuropathic pain

Published:2021 Issue:18 Volume:9 Page:6295-6307
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Kim Song I¹²^ORCID,Shin Juhee¹²^ORCID,Tran Quangdon¹²^ORCID,Park Hyewon¹²^ORCID,Kwon Hyeok Hee¹²^ORCID,Shin Nara¹²,Hwang Jeong-Ah¹²,Shin Hyo Jung¹²^ORCID,Lee Jiyong³,Lee Won Hyung³,Lee Sun Yeul³,Kim Dong Woon¹²^ORCID

Affiliation:

1. Department of Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea

2. Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea

3. Department of Anesthesia and Pain Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea

Abstract

Duloxetine (DLX) encapsulated PLGA nanoparticles were applied intrathecally into the spinal cord of spinal nerve ligation-induced neuropathic pain rats. DLX nanoparticles significantly alleviated pain behavior by enhanced targeting of microglia.

Funder

National Research Foundation of Korea

Chungnam National University Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00486G

Reference52 articles.

1. Neuropathic pain in the general population: A systematic review of epidemiological studies

2. Management of neuropathic pain