A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway-Reference-Cited by-同舟云学术

A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway

Published:2023 Issue:29 Volume:14 Page:7936-7943
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Jie¹^ORCID,Zhang Ruirui¹^ORCID,Mallick Shubhadip¹,Patil Sohan¹,Wientjens Chantal²,Flegel Jana¹,Krupp Anna³,Strohmann Carsten³,Grassin Corentin⁴^ORCID,Merten Christian⁴^ORCID,Pahl Axel¹⁵,Grigalunas Michael¹^ORCID,Waldmann Herbert¹²^ORCID

Affiliation:

1. Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Street 11, 44227 Dortmund, Germany

2. Faculty of Chemistry, Chemical Biology, Technical University Dortmund, Otto-Hahn-Street 6, 44221 Dortmund, Germany

3. Faculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Otto-Hahn-Street 6, 44221 Dortmund, Germany

4. Faculty of Chemistry and Biochemistry, Organic Chemistry II, Ruhr University Bochum, University-Street 150, 44801 Bochum, Germany

5. Compound Management and Screening Center, Otto-Hahn-Street 11, 44227 Dortmund, Germany

Abstract

Synthesis of pyrrolo[3,2-c]quinoline pseudo-natural products by means of a highly enantioselective intramolecular 1,3-dipolar cycloaddition yielded a novel Hedgehog signalling inhibitor chemotype that targets the Smoothened protein.

Funder

Max-Planck-Gesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01240A

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