The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase-Reference-Cited by-同舟云学术

The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase

Published:2017 Issue:13 Volume:53 Page:2182-2185
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yurkovich Marie E.¹²³⁴,Jenkins Robert⁵⁶⁴,Sun Yuhui⁷⁸⁹¹⁰¹¹,Tosin Manuela⁵⁶⁴^ORCID,Leadlay Peter F.¹²³⁴

Affiliation:

1. Department of Biochemistry

2. University of Cambridge

3. Cambridge

4. UK

5. Department of Chemistry

6. University of Warwick

7. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)

8. Ministry of Education

9. Wuhan University School of Pharmaceutical Sciences

10. Wuhan 430071

11. People's Republic of China

Abstract

Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructed via in vitro enzymology and chemical probes.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC09934C

Reference38 articles.

1. Chemical probing of thiotetronate bio-assembly

2. Antibacterial drug discovery in the resistance era

3. The re-emerging role of microbial natural products in antibiotic discovery

4. Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery

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