Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response-Reference-Cited by-同舟云学术

Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response

Published:2021 Issue:9 Volume:21 Page:1738-1751
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Walther Brandon K.¹²³⁴⁵^ORCID,Rajeeva Pandian Navaneeth Krishna¹²³^ORCID,Gold Karli A.¹²³,Kiliç Ecem S.¹²³^ORCID,Sama Vineeth¹⁶⁷³^ORCID,Gu Jianhua⁴⁵⁸⁹³,Gaharwar Akhilesh K.¹²³¹⁰²^ORCID,Guiseppi-Elie Anthony¹²³⁴⁵^ORCID,Cooke John P.⁴⁵⁸⁹³^ORCID,Jain Abhishek¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. Texas A&M University

3. USA

4. Department of Cardiovascular Sciences

5. Houston Methodist Institute for Academic Medicine

6. Clemson University

7. Clemson

8. Houston Methodist Research Institute

9. Houston

10. Department of Materials Science

Abstract

Walther et al. employed vessel-chip technology to study how matrix stiffness and shear stress combine to influence endothelial cell YAP mechanobiology, discovering that stiff matrices impede the protective effects of physiologic shear stress.

Funder

National Heart, Lung, and Blood Institute

Directorate for Engineering

National Institute of Biomedical Imaging and Bioengineering

Texas A and M University

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D0LC01283A