Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines-Reference-Cited by-同舟云学术

Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines

Published:2020 Issue:67 Volume:10 Page:40894-40903
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lakó Ágnes¹²³⁴⁵,Molnár Zsófia¹²³⁴,Mendonça Ricardo⁵⁶⁷⁸,Poppe László¹²³⁴⁹^ORCID

Affiliation:

1. Department of Organic Chemistry and Technology

2. Budapest University of Technology and Economics

3. 1111 Budapest

4. Hungary

5. Hovione Farmaciência, S.A.

6. Campus do Lumiar

7. 1649-038 Lisboa

8. Portugal

9. Biocatalysis and Biotransformation Research Center

Abstract

Immobilised whole-cell (R)-transaminases (TAs) enabled synthesis of either (R)- or (S)-enantiomers of drug-like amines from prochiral ketones or from racemic amines, respectively, in >95% ee.

Funder

Emberi Erőforrások Minisztériuma

Richter Gedeon Talentum Alapítvány

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA08134E

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