Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing
Author:
Affiliation:
1. Faculty of Engineering and Science
2. University of Greenwich
3. Chatham Maritime
4. UK
5. Cubi-Tech Extrusion Ltd.
6. CIPER Centre for Innovation and Process Engineering Research
Abstract
Solvent-free, continuous processing of high-quality pharmaceutical salts through via hot-melt extrusion as an alternative to solvent based approaches.
Funder
European Regional Development Fund
Publisher
Royal Society of Chemistry (RSC)
Subject
Pollution,Environmental Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/GC/C9GC03528A
Reference56 articles.
1. Guidance for industry: classification of pharmaceutical co-crystals. FDA guidance 2016, http://www.fda.gov/downloads/Drugs/Guidances/UCM516813.pdf
2. Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges
3. Salt screening and characterization of ciprofloxacin
4. Salt formation to improve drug solubility
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