Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles-Reference-Cited by-同舟云学术

Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles

Published:2021 Issue:12 Volume:12 Page:4547-4556
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Qiao Hongzhi¹²³⁴⁵,Zhang Lei⁶⁷⁸⁹⁴,Fang Dong⁶⁷⁸⁹⁴,Zhu Zhenzhu¹⁰¹¹³⁴⁵,He Weijiang¹²³⁴⁵^ORCID,Hu Lihong⁶⁷⁸⁹⁴,Di Liuqing⁶⁷⁸⁹⁴,Guo Zijian¹²³⁴⁵^ORCID,Wang Xiaoyong¹⁰¹¹³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Nanjing University

4. Nanjing 210023

5. China

6. Jiangsu Key Laboratory for Functional Substance of Chinese Medicine

7. Jiangsu Engineering Research Center for Efficient Delivery System of TCM

8. School of Pharmacy

9. Nanjing University of Chinese Medicine

10. State Key Laboratory of Pharmaceutical Biotechnology

11. School of Life Sciences

Abstract

Bcl-2-related tumor resistance to anticancer drugs can be overcome by silencing the cellular Bcl-2 gene via RNA interference. The realization of the goal is exemplified by delivering Bcl-2 siRNA and a tumor-resistant Cu complex to cancer cells with an ATP-responsive nanocarrier.

Funder

National Basic Research Program of China

China Association for Science and Technology

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Postdoctoral Science Foundation of Jiangsu Province

Qinglan Project of Jiangsu Province of China

Six Talent Peaks Project in Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry