Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(iv) prodrugs-Reference-Cited by-同舟云学术

Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(iv) prodrugs

Published:2020 Issue:15 Volume:11 Page:3829-3835
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Shuren¹²³⁴⁵,Zhong Xuanmeng¹²³⁴⁵,Yuan Hao¹²³⁴⁵,Guo Yan¹²³⁴⁵,Song Dongfan¹²³⁴⁵,Qi Fen¹²³⁴⁵,Zhu Zhenzhu⁶⁷⁵⁸,Wang Xiaoyong⁹¹⁰⁴⁵⁸^ORCID,Guo Zijian¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Chemistry and Biomedicine Innovation Centre

4. Nanjing University

5. Nanjing 210023

6. School of Food Science and Engineering

7. Nanjing University of Finance & Economics

8. P. R. China

9. State Key Laboratory of Pharmaceutical Biotechnology

10. School of Life Sciences

Abstract

Platinum(iv) prodrugs targeting the DNA repair mechanism downregulate myeloid cell leukemia-1 (Mcl-1) and homologous recombination proteins (RAD51, BRCA2), thereby enhancing cytotoxicity against cisplatin-resistant cancer cells.

Funder

National Natural Science Foundation of China

Nanjing University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC00197J

Reference66 articles.

1. Platinum coordination compounds with potent anticancer activity

2. Targeted delivery of platinum-based anticancer complexes