Molecular dynamics simulations and statistical coupling analysis of GPI12 in L. major: functional co-evolution and conservedness reveals potential drug–target sites

Author:

Singh Shailza1234,Mandlik Vineetha1234,Shinde Sonali1234

Affiliation:

1. National Centre for Cell Science

2. NCCS Complex

3. Pune 411007

4. India

Abstract

GPI12 represents an important enzyme in the GPI biosynthetic pathway of several parasites like ‘Leishmania’.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Reference27 articles.

1. M. A. J. Ferguson , T.Kinoshita and G. W.Hart, in Essentials of Glycobiology, ed. A. Varki, R. D. Cummings, J. D. Esko, H. H. Freeze, P. Stanley, C. R. Bertozzi, G. W. Hart and M. E. Etzler, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2nd edn, 2009

2. Innate Immune Activation and Subversion of Mammalian Functions byLeishmaniaLipophosphoglycan

3. Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63)

4. Expression Cloning of PIG-L, a CandidateN-Acetylglucosaminyl-phosphatidylinositol Deacetylase

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