Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles

Author:

Tardillo Suárez Vanessa1234ORCID,Karepina Elizaveta56789,Chevallet Mireille56789,Gallet Benoit1076511ORCID,Cottet-Rousselle Cécile5121334,Charbonnier Peggy56789,Moriscot Christine1076511,Michaud-Soret Isabelle56789ORCID,Bal Wojciech14151617,Fuchs Alexandra18194,Tucoulou Rémi1234,Jouneau Pierre-Henri5782021,Veronesi Giulia12345ORCID,Deniaud Aurélien56789ORCID

Affiliation:

1. ESRF

2. The European Synchrotron

3. 38000 Grenoble

4. France

5. Univ. Grenoble Alpes

6. CNRS

7. CEA

8. IRIG

9. Laboratoire de Chimie et Biologie des Métaux

10. Institut de Biologie Structurale

11. F-38042 Grenoble

12. INSERM U1055

13. Laboratory of Fundamental and Applied Bioenergetics (LBFA), and Environmental and System Biology (BEeSy)

14. Institute of Biochemistry and Biophysics

15. Polish Academy of Sciences

16. 02-106 Warsaw

17. Poland

18. DRF/BIG-INSERM U1160

19. F-75010 Paris

20. MEM

21. F-38000 Grenoble

Abstract

Upon exposure to non-toxic concentration of silver nanoparticles, only the ionic form of silver is found in the nucleus leading to an endocrine disruptor-like effect.

Funder

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Université Grenoble Alpes

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

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