Flavin-induced charge separation in transmembrane model peptides

Author:

Wörner Samantha1,Rauthe Pascal2,Werner Johannes2,Afonin Sergii3ORCID,Ulrich Anne S.13ORCID,Unterreiner Andreas-Neil2ORCID,Wagenknecht Hans-Achim1ORCID

Affiliation:

1. Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany

2. Institute of Physical Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 2, 76131 Karlsruhe, Germany

3. Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG2), POB 3640, 76021 Karlsruhe, Germany

Abstract

Flavin-modified peptide models from the α-helical transmembrane segment of the epidermal growth factor receptor were synthetically altered. A flavin amino acid was used as a photo-inducible charge donor, with tryptophans along the helix as acceptors.

Funder

Deutsche Forschungsgemeinschaft

Karlsruher Institut für Technologie

Publisher

Royal Society of Chemistry (RSC)

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