Unexpected reversible and controllable nuclear uptake and efflux of the DNA “light-switching” Ru(ii)-polypyridyl complex in living cellsviaion-pairing with chlorophenolate counter-anions
Author:
Affiliation:
1. State Key Laboratory of Environmental Chemistry and Ecotoxicology
2. Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences
3. Chinese Academy of Sciences
4. Beijing
5. China
Abstract
An in-depth understanding of the mechanisms of cellular uptake and efflux would facilitate the design of metal complexes with not only better functionality and targeted theranostic efficiency, but also with controlled toxicity.
Funder
National Natural Science Foundation of China
Chinese Academy of Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2020/TB/D0TB00821D
Reference50 articles.
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4. Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes as anticancer drug candidates
5. Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy
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1. Unprecedented enantio-selective live-cell mitochondrial DNA super-resolution imaging and photo-sensitizing by the chiral ruthenium polypyridyl DNA “light-switch”;Nucleic Acids Research;2023-11-02
2. Unusual enantioselective cytoplasm-to-nucleus translocation and photosensitization of the chiral Ru(II) cationic complex via simple ion-pairing with lipophilic weak acid counter-anions;Nucleic Acids Research;2023-03-20
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4. The cell-impermeable Ru(II) polypyridyl complex as a potent intracellular photosensitizer under visible light irradiation via ion-pairing with suitable lipophilic counter-anions;Free Radical Biology and Medicine;2021-08
5. Potent oxidation of DNA by Ru(ii) tri(polypyridyl) complexes under visible light irradiation via a singlet oxygen-mediated mechanism;Inorganic Chemistry Frontiers;2021
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