Potent oxidation of DNA by Ru(ii) tri(polypyridyl) complexes under visible light irradiation via a singlet oxygen-mediated mechanism

Author:

Shao Jie12345ORCID,Yan Zhu-Ying12345,Tang Miao12345,Huang Chun-Hua12345ORCID,Sheng Zhi-Guo12345,Chen Jing12345,Shao Bo12345,Zhu Ben-Zhan12345

Affiliation:

1. State Key Laboratory of Environmental Chemistry and Eco-toxicology

2. Research Centre for Eco-environmental Sciences and University of the Chinese Academy of Sciences

3. the Chinese Academy of Sciences

4. Beijing 100085

5. PR China

Abstract

The irradiation of Ru(ii) tri(polypridyl) complexes with visible light can induce potent oxidation of DNA mediated by 1O2via a type II photosensitization mechanism.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference89 articles.

1. Oxidative Nucleobase Modifications Leading to Strand Scission

2. Singlet Oxygen Oxidation of Isolated and Cellular DNA: Product Formation and Mechanistic Insights

3. J. Cadet and P. D.Mascio , Peroxides in biological systems, In patai series: the chemistry of functional groups. The chemistry of peroxides , Wiley , New York , 2006 , vol. 2 , pp. 915–1000

4. Singlet oxygen sensitisation by excited state DNA

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