A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics-Reference-Cited by-同舟云学术

A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

Published:2022 Issue:19 Volume:147 Page:4275-4284
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Iwamoto Noriko¹,Koguchi Yoshinobu²,Yokoyama Kotoko³,Hamada Akinobu⁴,Yonezawa Atsushi⁵,Piening Brian D.²,Tran Eric²,Fox Bernard A.²,Redmond William L.²,Shimada Takashi¹^ORCID

Affiliation:

1. Shimadzu Bioscience Research Partnership, Shimadzu Scientific Instruments, 21720 23rd Dr SE, Bothell, WA 98021, USA

2. Earle A. Chiles Research Institute, Providence Cancer Institute, 4805 NE Glisan St., Portland, OR 97213, USA

3. Global Application Development Center, Shimadzu Corporation, Nishinokyo-Kuwabaracho, Nakagyo-ku, Kyoto 604-8511, Japan

4. Division of Molecular Pharmacology, National Cancer Center, 5-1-1 Tsukuji, Chuo-ku, Tokyo 104-0045, Japan

5. Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan

Abstract

Accurate multiplexed quantitation of unique signature peptides derived from monoclonal antibody therapeutics with a universal reference antibody refmAb-Q using Fab-selective proteolysis nSMOL coupled with LC-MS/MS.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AN/D2AN01032A

Reference62 articles.

1. FDA approves 100th monoclonal antibody product

2. Antibodies to watch in 2021

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4. A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients

5. Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development

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