Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Published:2014 Issue:20 Volume:12 Page:3288-3302
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mingozzi M.¹²³,Manzoni L.⁴⁵⁶,Arosio D.⁴⁵⁶,Dal Corso A.¹²³,Manzotti M.¹²³,Innamorati F.¹²³,Pignataro L.¹²³,Lecis D.⁷⁸⁹,Delia D.⁷⁸⁹,Seneci P.¹²³,Gennari C.¹²³

Affiliation:

1. Università degli Studi di Milano

2. Dipartimento di Chimica

3. Milan, Italy

4. Istituto di Scienze e Tecnologie Molecolari

5. Consiglio Nazionale delle Ricerche

6. I-20133 Milano, Italy

7. Fondazione IRCCS Istituto Nazionale dei Tumori

8. Dipartimento di Oncologia Sperimentale e Medicina Molecolare

9. I-20133 Milan, Italy

Abstract

Dual action cyclo-RGD/SMAC mimetic conjugates endowed with in vitro activity against anti-apoptotic IAPs and pro-angiogenetic integrins are reported.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00207E

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