3D magnetically controlled spatiotemporal probing and actuation of collagen networks from a single cell perspective

Author:

Asgeirsson Daphne O.1ORCID,Christiansen Michael G.1ORCID,Valentin Thomas1,Somm Luca1,Mirkhani Nima1ORCID,Nami Amin Hosseini2,Hosseini Vahid34ORCID,Schuerle Simone1ORCID

Affiliation:

1. Responsive Biomedical Systems Laboratory, Department of Health Science and Technology, ETH Zurich, 8093 Zurich, Switzerland

2. Department of Biotechnology, College of Science, University of Tehran, Tehran 1417614411, Iran

3. Department of Bioengineering, University of California, Los Angeles, CA 90095, USA

4. Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA

Abstract

Rod-shaped magnetic microprobes are employed to assess and actuate extracellular matrix models in 3D from the perspective of single cells. To achieve this, our method combines magnetic field control, physical modeling, and image analysis.

Funder

Eidgenössische Technische Hochschule Zürich

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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