Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds
Author:
Affiliation:
1. SPOTS-LAB – Sustainable Pharmaceutical and Organic Technology and Synthesis Laboratory
2. Department of Pharmacy
3. University of Naples ‘Federico II’
4. 80131 Naples
5. Italy
Abstract
3,3-Disubstituted indolenines are obtained via a green and sustainable flow chemistry protocol for interrupted Fischer indolisation reactions.
Funder
Ministero dell’Istruzione, dell’Università e della Ricerca
Regione Campania
Publisher
Royal Society of Chemistry (RSC)
Subject
Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RE/D0RE00329H
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5. Identification of 5-(2,3-Dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model
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