Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds

Author:

Alfano Antonella Ilenia12345,Zampella Angela12345ORCID,Novellino Ettore12345ORCID,Brindisi Margherita12345ORCID,Lange Heiko12345ORCID

Affiliation:

1. SPOTS-LAB – Sustainable Pharmaceutical and Organic Technology and Synthesis Laboratory

2. Department of Pharmacy

3. University of Naples ‘Federico II’

4. 80131 Naples

5. Italy

Abstract

3,3-Disubstituted indolenines are obtained via a green and sustainable flow chemistry protocol for interrupted Fischer indolisation reactions.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Regione Campania

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

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