Facile synthesis of 2,3-benzodiazepines using one-pot two-step phosphate-assisted acylation–hydrazine cyclization reactions-Reference-Cited by-同舟云学术

Facile synthesis of 2,3-benzodiazepines using one-pot two-step phosphate-assisted acylation–hydrazine cyclization reactions

Published:2018 Issue:21 Volume:16 Page:4013-4020
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sumita Akinari¹²³⁴,Lee Jinhee¹²³⁴⁵,Otani Yuko¹²³⁴^ORCID,Ohwada Tomohiko¹²³⁴^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. The University of Tokyo

3. Tokyo

4. Japan

5. Lloyd L. Gregory School of Pharmacy

Abstract

We present a one-pot two-step methodology, in which an unprotected amino is tolerated, for rapidly synthesizing 2,3-benzodiazepines via phosphate-assisted acylation reaction and hydrazine cyclization reaction.

Funder

Japan Society for the Promotion of Science

University of Tokyo

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00708J

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