Enzymatic isolation and microfluidic electrophoresis analysis of residual dsRNA impurities in mRNA vaccines and therapeutics-Reference-Cited by-同舟云学术

Enzymatic isolation and microfluidic electrophoresis analysis of residual dsRNA impurities in mRNA vaccines and therapeutics

Published:2024 Issue:5 Volume:149 Page:1509-1517
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Coll De Peña Adriana¹^ORCID,Vaduva Matei²,Li Nina S.¹,Shah Shreyas³,Ben Frej Menel³,Tripathi Anubhav¹^ORCID

Affiliation:

1. Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, USA

2. Department of Molecular Biology, Cell Biology, and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, USA

3. Applied Genomics, Revvity, Hopkinton, MA, USA

Abstract

The versatility, rapid development, and ease of production scalability of mRNA have placed them at the forefront of biopharmaceutical research. Here, we present an analytical method that can support their development and production optimization.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D3AN02157B

Reference31 articles.

1. Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing

2. An overview of rational design of mRNA-based therapeutics and vaccines

3. mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

4. mRNA vaccines — a new era in vaccinology

5. RNA Therapeutics - Research and Clinical Advancements

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1. Electrophoretic Microfluidic Characterization of mRNA- and pDNA-Loaded Lipid Nanoparticles;ACS Applied Materials & Interfaces;2024-05-16

2. A (RP)UHPLC/UV analytical method to quantify dsRNA during the mRNA vaccine manufacturing process;Analytical Methods;2024