A (RP)UHPLC/UV analytical method to quantify dsRNA during the mRNA vaccine manufacturing process-Reference-Cited by-同舟云学术

A (RP)UHPLC/UV analytical method to quantify dsRNA during the mRNA vaccine manufacturing process

Published:2024 Issue:30 Volume:16 Page:5146-5153
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Rosa Sara Sousa¹²³,Zhang Shuran¹,Sari Yustika¹,Marques Marco P. C.¹^ORCID

Affiliation:

1. Department of Biochemical Engineering, University College London, Gordon Street, London, WC1E 6BT, UK

2. Department of Bioengineering, iBB—Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

3. Associate Laboratory i4HB—Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

Abstract

Development of an HPLC method to quantify dsRNA, a product related impurity, produced during mRNA vaccine manufacturing. This method allows to quantify dsRNA in single samples in under 30 min.

Funder

Fundação para a Ciência e a Tecnologia

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AY/D4AY00560K

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