Bottlebrush copolymers for gene delivery: influence of architecture, charge density, and backbone length on transfection efficiency-Reference-Cited by-同舟云学术

Bottlebrush copolymers for gene delivery: influence of architecture, charge density, and backbone length on transfection efficiency

Published:2022 Issue:19 Volume:10 Page:3696-3704
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Floyd Thomas G.¹,Song Ji-Inn¹,Hapeshi Alexia¹,Laroque Sophie¹,Hartlieb Matthias²³^ORCID,Perrier Sébastien¹⁴⁵^ORCID

Affiliation:

1. Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK

2. Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476, Potsdam, Germany

3. Fraunhofer Institute for Applied Polymer Research (IAP), Geiselbergstraße 69, Potsdam-Golm, Germany

4. Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK

5. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia

Abstract

The influence of polymer architecture of cationic polymers on gene transfection is investigated. Bottle brush copolymers are shown to outperform linear counterparts.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00490A

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