Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites-Reference-Cited by-同舟云学术

Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites

Published:2023 Issue:40 Volume:13 Page:27696-27704
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Doyle Bradley¹,Madden Leigh A.²^ORCID,Pamme Nicole¹³^ORCID,Jones Huw S.⁴

Affiliation:

1. School of Natural Sciences, University of Hull, HU6 7RX, UK

2. Centre for Biomedicine, University of Hull, HU6 7RX, UK

3. Department of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden

4. Institute of Cancer Therapeutics, University of Bradford, BD7 1DP, UK

Abstract

On-chip continuous-flow synthesis of metabolites from glucuronidation and sulfonation reactions to enable synthesis of analytical standards and study drug metabolism.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA03742H

Reference52 articles.

1. S. T.Susa and C. V.Preuss , in StatPearls , Treasure Island, FL , 2022

2. Metabolites in safety testing

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4. An analysis of the attrition of drug candidates from four major pharmaceutical companies

5. “Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism

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