Enzymatic syntheses of novel carbocyclic scaffolds with a 6,5 + 5,5 ring system by squalene-hopene cyclase
Author:
Affiliation:
1. Department of Applied Biological Chemistry
2. Faculty of Agriculture
3. and Graduate School of Science and Technology
4. Niigata University
5. Niigata
Abstract
A novel scaffold with a 6,5 + 5, 5 ring system (allodammarane) was synthesized from 27-norsqualene (13a), 3R-(18) and 3S-27-noroxidosqualenes (19).
Funder
Japan Society for the Promotion of Science
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01941C
Reference30 articles.
1. Enzyme Mechanisms for Polycyclic Triterpene Formation
2. Squalene–hopene cyclase: catalytic mechanism and substrate recognition
3. A Case Study in Biomimetic Total Synthesis: Polyolefin Carbocyclizations to Terpenes and Steroids
4. Mutagenesis approaches to deduce structure–function relationships in terpene synthases
5. Enzymatic synthesis of cyclic triterpenes
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