Uridine inhibits the stemness of intestinal stem cells in 3D intestinal organoids and mice

Author:

Liu Yi-Lin12345,Guo Song-Ge12345,Xie Chun-yan678910,Niu Kaimin11121310,De Jonge Hugo14151617,Wu Xin12345ORCID

Affiliation:

1. Key Laboratory of Agro-ecological Processes in Subtropical Region

2. Institute of Subtropical Agriculture

3. Chinese Academy of Sciences

4. Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production

5. Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process

6. College of Resources and Environment

7. College of Bioscience and Biotechnology

8. Hunan Agricultural University

9. Changsha

10. China

11. Institute of Biological Resources

12. Jiangxi Academy of Sciences

13. Nanchang 330096

14. Department of Gastroenterology and Hepatology

15. Erasmus MC University Medical Center

16. Rotterdam

17. Netherlands

Abstract

The activity of intestinal stem cells (ISCs) is foremost in maintaining homeostasis and repair of intestines.

Funder

National Basic Research Program of China

Hunan Provincial Science and Technology Department

Chinese Academy of Sciences

China Sponsorship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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