Comparative oral and intravenous pharmacokinetics of phlorizin in rats having type 2 diabetes and in normal rats based on phase II metabolism-Reference-Cited by-同舟云学术

Comparative oral and intravenous pharmacokinetics of phlorizin in rats having type 2 diabetes and in normal rats based on phase II metabolism

Published:2019 Issue:3 Volume:10 Page:1582-1594
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Zhanguo¹²³⁴⁵,Gao Ziyang⁶⁷⁵⁸,Wang Anqi⁹¹⁰¹¹¹²¹³,Jia Lan⁶⁷⁵⁸,Zhang Xiaoyu⁶⁷⁵⁸^ORCID,Fang Ming¹²³⁴⁵,Yi Kang⁶⁷⁵⁸,Li Qijuan¹⁴¹⁵¹⁶⁸,Hu Huiling¹⁴¹⁵¹⁶⁸

Affiliation:

1. Chengdu Holistic Integrative Medicine Collaborative Innovation Research Center

2. Aba Tibetan and Qiang Medicine Quality Evaluation Innovation Research Laboratory

3. School of Medicine and Nursing

4. Chengdu University

5. Longquan

6. College of Life Sciences

7. Sichuan Normal University

8. China

9. State Key Laboratory of Quality Research in Chinese Medicine

10. Institute of Chinese Medical Sciences

11. University of Macau

12. Avenida da Universidade

13. Macau 999078

14. School of Pharmacy

15. Chengdu University of Traditional Chinese Medicine

16. Wenjiang, Chengdu 610730

Abstract

Phlorizin (PHZ), a type of dihydrochalcone widely found in Rosaceae such as apples, is the first compound discovered as a sodium-glucose cotransporter (SGLT) inhibitor.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C8FO02242A

Reference53 articles.

1. Dietary Phloridzin Reduces Blood Glucose Levels and Reverses Sglt1 Expression in the Small Intestine in Streptozotocin-Induced Diabetic Mice

2. Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats

3. Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice

4. Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice

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