Engineered zinc oxide-based nanotherapeutics boost systemic antibacterial efficacy against phloem-restricted diseases

Author:

Soliman Mikhael12,Lee Briana1,Ozcan Ali13ORCID,Rawal Takat B.45,Young Mikaeel16,Mendis Hajeewaka C.17,Rajasekaran Parthiban1,Washington Torus1,Pingali Sai Venkatesh8,O'Neill Hugh58,Gesquiere Andre13,De La Fuente Leonardo7,Petridis Loukas45ORCID,Johnson Evan9,Graham James9,Santra Swadeshmukul1236,Tetard Laurene110ORCID

Affiliation:

1. NanoScience Technology Center, University of Central Florida, Orlando, FL, 32826, USA

2. Department of Material Science Engineering, University of Central Florida, Orlando, FL, 32816, USA

3. Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA

4. UT/ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA

5. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, USA

6. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA

7. Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA

8. Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA

9. Citrus Research and Education Center, University of Florida, Lake Alfred, Florida 33850, USA

10. Department of Physics, University of Central Florida, Orlando, FL 32816, USA

Abstract

Defect engineering at the surface of zinc oxide sub-5 nm nanoparticles provides a systemic nanotherapeutic with significant field efficacy against citrus HLB disease.

Funder

Citrus Research and Development Foundation

National Institute of Food and Agriculture

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

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