Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases-Reference-Cited by-同舟云学术

Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases

Published:2021 Issue:20 Volume:23 Page:8096-8107
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Martelli Giulia¹^ORCID,Cantelmi Paolo¹,Palladino Chiara¹,Mattellone Alexia¹^ORCID,Corbisiero Dario¹,Fantoni Tommaso¹,Tolomelli Alessandra¹^ORCID,Macis Marco²,Ricci Antonio²,Cabri Walter¹^ORCID,Ferrazzano Lucia¹

Affiliation:

1. P4i Lab, Department of Chemistry, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy

2. Innovation and Development, Fresenius kabi iPsum, via San Leonardo 23, 45010-RO, Italy

Abstract

Solid Phase Peptide Synthesis (SPPS) is a key technology for the production of pharmaceutical grade peptides and the replacement of piperidine with alternative bases is a piece of the puzzle moving toward a greener technology.

Funder

Università di Bologna

Fresenius Kabi

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/GC/D1GC02634H

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