Green Solid-Phase Peptide Synthesis: Oxyma-Triggered Spectrophotometric Monitoring of Residual Piperidine

Author:

Broman So̷ren Lindbæk1,Rosenberg Martin1,Wojcik Felix2,Holm Hansen Anders3,Egelund Peter Hammer Guldager1ORCID,Malmstro̷m Joan4,Sejer Pedersen Daniel1ORCID

Affiliation:

1. Novo Nordisk A/S, CMC API Development, Chemical Development, Novo Allé, DK-2880 Bagsværd, Denmark

2. Novo Nordisk A/S, Research Chemistry, Novo Nordisk Park, DK-2760 Målo̷v, Denmark

3. Novo Nordisk A/S, CMC API Pilots, Chemistry Pilot, Novo Allé, DK-2880 Bagsværd, Denmark

4. Novo Nordisk A/S, CMC Analytical Support, Novo Nordisk Park, DK-2760 Målo̷v, Denmark

Publisher

American Chemical Society (ACS)

Reference30 articles.

1. Peptide Therapeutics Market Size, Share & Trends Analysis Report By Application, By Type, By Type of Manufacturers, By Route of Administration, By Synthesis Technology, By Region, And Segment Forecasts, 2022–2030; Grand View Research: San Francisco, 2022.

2. Peptide-based drug discovery: Current status and recent advances

3. Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

4. Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

5. Trimming synthetic peptide and oligonucleotide waste-lines

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