Synthesis of metergoline analogues and their evaluation as antiplasmodial agents-Reference-Cited by-同舟云学术

Synthesis of metergoline analogues and their evaluation as antiplasmodial agents

Published:2014 Issue:2 Volume:5 Page:165-170
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Singh Kawaljit¹²³,Kaur Gurminder¹²³,Mjambili Faith¹²³,Smith Peter J.⁴²⁵,Chibale Kelly¹²³

Affiliation:

1. Department of Chemistry and Institute of Infectious Disease & Molecular Medicine

2. University of Cape Town

3. Rondebosch 7701, South Africa

4. Medical School

5. , South Africa

Abstract

A series of metergoline analogues were synthesized and evaluatedin vitrofor antiplasmodial activity and cytotoxicity towards a mammalian cell line. Some of the compounds exhibited promising selective antiplasmodial activity along with a high selectivity index relative to metergoline.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00310H

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