Mitochondria-targeted alginate/triphenylphosphonium-grafted-chitosan for treatment of hepatocellular carcinoma-Reference-Cited by-同舟云学术

Mitochondria-targeted alginate/triphenylphosphonium-grafted-chitosan for treatment of hepatocellular carcinoma

Published:2022 Issue:34 Volume:12 Page:21690-21703
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Arafa Kholoud K.¹^ORCID,Hamzawy Mohamed A.²,Mousa Shaker A.³,El-Sherbiny Ibrahim M.¹^ORCID

Affiliation:

1. Nanomedicine Research Labs, Center for Materials Science (CMS), Zewail City of Science and Technology, Ahmed Zewail Road, October Gardens, 6th of October City, 12578, Giza, Egypt

2. Pharmacology & Toxicology Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt

3. Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA

Abstract

Mitochondrial targeting of anticancer drugs can effectively eradicate tumour cells. TPP+-grafted-chitosan based core–shell nanoparticles were successfully internalized into the mitochondria of HCC cells. Also exhibited antiproliferative activity against liver cancer.

Funder

Academy of Scientific Research and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03240F

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