Ring-opened aminothienopyridazines as novel tau aggregation inhibitors-Reference-Cited by-同舟云学术

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Ring-opened aminothienopyridazines as novel tau aggregation inhibitors

Published:2017 Issue:6 Volume:8 Page:1275-1282
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Moir M.¹²³⁴,Chua S. W.⁵⁶⁷⁸³,Reekie T.¹²³⁴,Martin A. D.⁵⁶⁷⁸³^ORCID,Ittner A.⁵⁶⁷⁸³,Ittner L. M.⁵⁶⁷⁸³,Kassiou M.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Sydney

3. Sydney

4. Australia

5. Dementia Research Unit

6. School of Medical Sciences

7. Faculty of Medicine

8. University of New South Wales

Abstract

Simplified aminothienopyridazine analogues were synthesised and their inhibition of tau protein aggregation assessed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00306K

Reference20 articles.

1. Global prevalence of dementia: a Delphi consensus study

2. A protein factor essential for microtubule assembly.

3. Alzheimer's Disease: The Amyloid Cascade Hypothesis

4. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

5. Neuropathological stageing of Alzheimer-related changes

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