Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

Author:

Qin Wei12345,Zhang Pengfei12345ORCID,Li Hui678910,Lam Jacky W. Y.12345,Cai Yuanjing1112131415ORCID,Kwok Ryan T. K.12345,Qian Jun1617181920ORCID,Zheng Wei678910,Tang Ben Zhong12345

Affiliation:

1. Department of Chemistry

2. Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction

3. Institute for Advanced Study

4. Division of Biomedical Engineering

5. State Key Laboratory of Molecular Neuroscience and Division of Life Science

6. Research Laboratory for Biomedical Optics and Molecular Imaging

7. Shenzhen Key Laboratory for Molecular Imaging

8. Institute of Biomedical and Health Engineering

9. Shenzhen Institutes of Advanced Technology

10. Chinese Academy of Sciences

11. NSFC Center for Luminescence from Molecular Aggregate

12. SCUT-HKUST Joint Research Laboratory

13. State Key Laboratory of Luminescent Materials and Devices

14. South China University of Technology

15. Guangzhou 510640

16. State Key Laboratory of Modern Optical Instrumentations

17. Center for Optical and Electromagnetic Research

18. JORCEP (Sino-Swedish Joint Research Center of Photonics) Zhejiang University

19. Hangzhou 310058

20. China

Abstract

A successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features is reported. The AIE dots can be utilized as efficient fluorescent probes for in vivo deep-tissue imaging with high penetration depth and high contrast.

Funder

National Natural Science Foundation of China

Innovation and Technology Commission

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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