1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, CREST, JST Agency, Kawaguchi, Saitama, Japan, Keio University, School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan, and The University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo, Japan